SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis.

Tong XuXichuan LiWennan ZhaoXue WangLeixin JinZhiqiang FengHuixiang LiMingzhe ZhangYiqing TianGe HuYuan YueXintong DaiChangliang ShanWeihua ZhangChunze ZhangYoucai Zhang

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our findings revealed that SF3B3 promoted CRC progression and metastasis by regulating mTOR alternative splicing and SREBF1-FASN-mediated lipogenesis, providing strong evidence to support SF3B3 as a druggable target for CRC therapy.

Keyphrases

cell proliferation
transcription factor
single cell
stem cells
type diabetes
adipose tissue
cell therapy
insulin resistance