CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.

Juan WuYueran LiShuwei TianShufang NaHongyan WeiYafei WuYafei YangZixia ShenJiayue DingShenglan BaoSiqi LiuLingyun LiRongling FengYong ZhuChunyan HeJiang Yue

Published in: CNS neuroscience & therapeutics (2024)

Brain CYP1B1 plays a critical role in both cerebrovascular and dopamine homeostasis, which might serve as a novel therapeutic target for the prevention of Mn-induced neurotoxicity.

Keyphrases

diabetic rats
oxidative stress
high glucose
dna damage
multiple sclerosis
uric acid
ischemia reperfusion injury
signaling pathway
induced apoptosis
prefrontal cortex