Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways.

Jun-Sheng Tian Zhen-Ning WuDan WuChen YangYao GaoDong-Lan YanXue-Mei Qin

Published in: Metabolic brain disease (2023)

Based on the results of network pharmacology and animal experiment validation, Chaigui granules may reverse CUMS-induced depression-like behavior in rats through PI3K/Akt/mTOR signaling pathway.

Keyphrases

signaling pathway
depressive symptoms
pi k akt
sleep quality
epithelial mesenchymal transition
high glucose
induced apoptosis
diabetic rats
genome wide
drug induced
endothelial cells
gene expression
oxidative stress