The landscape of tolerated genetic variation in humans and primates.
Hong GaoTobias HampJeffrey EdeJoshua G SchraiberJeremy McRaeMoriel Singer-BerkYanshen YangAnastasia DietrichPetko FizievLukas KudernaLaksshman SundaramYibing WuAashish AdhikariYair FieldChen ChenSerafim BatzoglouFrancois AguetGabrielle LemireRebecca ReimersDaniel BalickMareike C JaniakMartin KuhlwilmJoseph D OrkinShivakumara ManuAlejandro ValenzuelaJuraj BergmanMarjolaine RouselleFelipe Ennes SilvaLidia AguedaJulie BlancMarta GutDorien de VriesIan GoodheadR Alan HarrisMuthuswamy RaveendranAxel JensenIdriss S ChumaJulie HorvathChristina HvilsomDavid JuanPeter FrandsenFabiano R de MeloFabricio BertuolHazel ByrneIracilda SampaioIzeni FariasJoão Valsecchi do AmaralMariluce MessiasMaria N F da SilvaMihir TrivediRogerio RossiTomas HrbekNicole AndriaholinirinaClément J RabarivolaAlphonse ZaramodyClifford J JollyJane Phillips-ConroyGregory WilkersonChristian AbeeJoe H SimmonsEduardo Fernandez-DuqueEe KanthaswamyFekadu ShiferawDongdong WuLong ZhouYong ShaoGuojie ZhangJulius D KeyyuSascha KnaufMinh D LeEsther LizanoStefan MerkerArcadi NavarroThomas BatallionTilo NadlerChiea Chuen KhorJessica LeePatrick TanWeng Khong LimAndrew C KitchenerDietmar ZinnerIvo Glynne GutAmanda MelinKaterina GuschanskiMikkel Heide SchierupRobin M D BeckGovindhaswamy UmapathyChristian RoosJean P BoubliMonkol LekShamil SunyaevAnne H O'Donnell-LuriaMichael J BamshadJinbo XuJeffrey RogersTomas Marques-BonetKyle Kai-How FarhPublished in: bioRxiv : the preprint server for biology (2023)
Deep learning classifier trained on 4.3 million common primate missense variants predicts variant pathogenicity in humans.