Rate of response to initial antiretroviral therapy according to level of pre-existing HIV-1 drug resistance detected by next-generation sequencing in the strategic timing of antiretroviral treatment (START) study.
Alessandro Cozzi-LepriDavid DunnAnna TostevinRasmus L MarvigMarc BennedbaekShweta SharmaMichael J KozalMark GompelsAngie N PintoJens LundgrenJohn D Baxternull nullPublished in: HIV medicine (2023)
Up to 17% of participants initiated ART with a GSS <3 on the basis of NGS data. Minority variants were predictive of TF, especially for participants starting NNRTI-based regimens.