Vitamin A deficiency exacerbates extrinsic atopic dermatitis development by potentiating type 2 helper T cell-type inflammation and mast cell activation.

Huan YangJing-Si ChenWen-Jing ZouQi TanYi-Zhu XiaoXiao-Yan LuoPeisong GaoZhou FuHua Wang

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

VAD can exacerbate extrinsic AD by augmenting Th2-mediated inflammation and mast cell activation. Therapeutic VAS can rescue VAD-aggravated eAD. It may provide a new strategy for future prevention or treatment of atopic dermatitis.

Keyphrases

atopic dermatitis
oxidative stress
dendritic cells
current status
replacement therapy
immune response