A division of labor in mTORC1 signaling and autophagy.

Published in: Science signaling (2018)

In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor.

Keyphrases

cell death
signaling pathway
endoplasmic reticulum stress
oxidative stress
induced apoptosis
epithelial mesenchymal transition
small molecule
protein protein
transcription factor