Inhibitory effects of fluoxetine on the secretion of inflammatory mediators and JAK/STAT3 and JNK/TLR4 gene expression.

Hoda Mojiri-Forushani Elham Khajehali Maryam Adelipour Zahra Nazeri

Published in: Molecular biology reports (2022)

The findings revealed that fluoxetine has anti-inflammatory properties, mainly due to the reduction of inflammatory cytokines and inhibition of JAK/STAT3 and TLR4/JNK gene expression in macrophages.

Keyphrases

gene expression
toll like receptor
inflammatory response
anti inflammatory
signaling pathway
dna methylation
cell death
immune response
induced apoptosis
oxidative stress
single cell