Refractory neutrophils and monocytes in patients with inflammatory bowel disease after repeated bouts of prolonged exercise.
Roy SpijkermanLillian HesselinkCarlo BertinettoCoen C W G BongersFalco HietbrinkNienke VrisekoopLuke P H LeenenMaria T E HopmanJeroen J JansenLeo KoendermanPublished in: Cytometry. Part B, Clinical cytometry (2021)
Increased responsiveness of neutrophils and monocyte to fMLF was demonstrated after repetitive bouts of prolonged exercise. Interestingly, this exercise was associated with relative refractoriness of both neutrophils and monocytes in IBD patients. These refractory cells might create a lower inflammatory state in the intestine providing a putative mechanism for the decrease in flare-ups in IBD patients after repeated exercise.
Keyphrases
- end stage renal disease
- high intensity
- chronic kidney disease
- newly diagnosed
- physical activity
- dendritic cells
- prognostic factors
- peritoneal dialysis
- oxidative stress
- resistance training
- patients with inflammatory bowel disease
- high frequency
- cell death
- patient reported outcomes
- immune response
- cell proliferation
- body composition
- patient reported
- cell cycle arrest