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Formulation and characterization of antibiotic drug loaded aquasome for the topical application.

Bhuvaneshwari ShanmugamUmashankar Marakanam Srinivasan
Published in: Future science OA (2024)
Aim: This study aimed to develop a topical antibiotic drug delivery system using aquasomes for enhanced treatment of skin and soft tissue infections (SSTIs). Materials & methods: Cephalothin was loaded into aquasomes using a multi-step process and optimized using design of experiment. The aquasomes were characterized for FT-IR, SEM and zeta potential analysis. Entrapment efficacy, In vitro drug release studies, antibacterial assays and stability study was performed to evaluate the efficacy of the formulated aquasomes. Results & conclusion: The formulated cephalothin-loaded aquasomes exhibited stable properties, controlled drug release and significant antibacterial activity against bacteria. This proves that the developed aquasome-based delivery system has the potential for sustained treatment of SSTIs.
Keyphrases
  • drug release
  • drug delivery
  • wound healing
  • soft tissue
  • cancer therapy
  • emergency department
  • human health
  • silver nanoparticles
  • climate change
  • adverse drug
  • anti inflammatory
  • data analysis