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Platelet-conditioned media induces an anti-inflammatory macrophage phenotype through EP4.

Sean P HeffronAda WeinstockBianca ScolaroShiyu ChenBrian E SansburyGreg MareckiChristina C RollingHanane El BannoudiTessa J BarrettJames W CanaryMatthew SpiteJeffrey S BergerEdward A Fisher
Published in: Journal of thrombosis and haemostasis : JTH (2020)
Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. Our findings suggest that therapies targeting hemostatic properties of platelets, while not influencing pro-resolving, immune-related activities, could be beneficial for the treatment of atherothrombotic disease.
Keyphrases
  • anti inflammatory
  • adipose tissue
  • cancer therapy
  • combination therapy
  • drug delivery
  • drug induced
  • smoking cessation