Platelet-conditioned media induces an anti-inflammatory macrophage phenotype through EP4.

Sean P HeffronAda WeinstockBianca ScolaroShiyu ChenBrian E SansburyGreg MareckiChristina C RollingHanane El BannoudiTessa J BarrettJames W CanaryMatthew SpiteJeffrey S BergerEdward A Fisher

Published in: Journal of thrombosis and haemostasis : JTH (2020)

Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. Our findings suggest that therapies targeting hemostatic properties of platelets, while not influencing pro-resolving, immune-related activities, could be beneficial for the treatment of atherothrombotic disease.

Keyphrases

anti inflammatory
adipose tissue
cancer therapy
combination therapy
drug delivery
drug induced
smoking cessation