Platelet-conditioned media induces an anti-inflammatory macrophage phenotype through EP4.
Sean P HeffronAda WeinstockBianca ScolaroShiyu ChenBrian E SansburyGreg MareckiChristina C RollingHanane El BannoudiTessa J BarrettJames W CanaryMatthew SpiteJeffrey S BergerEdward A FisherPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. Our findings suggest that therapies targeting hemostatic properties of platelets, while not influencing pro-resolving, immune-related activities, could be beneficial for the treatment of atherothrombotic disease.