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[Research advances in mechanistic signaling in pulmonary fibrosis].

X ChenY M Zhu
Published in: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (2024)
Pulmonary fibrosis is a complex and intractable disease characterized by extracellular matrix accumulation and altered mechanical properties of lung tissue. Biomechanical properties are closely related to the development, progression, and treatment of tissue fibrosis. In this review, we summarized the changes in the pulmonary biomechanical microenvironment, highlight the role of mechanotransduction in pulmonary fibrosis, and describe recent clinical advances targeting mechanical signals to alleviate pulmonary fibrosis.
Keyphrases
  • pulmonary fibrosis
  • extracellular matrix
  • stem cells
  • pulmonary hypertension
  • cancer therapy
  • finite element
  • finite element analysis
  • drug delivery