Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1.

Mirjam de WithLeni van DoornEsmay KloetAnne van VeggelMaja MaticMicha J de NeijsEsther Oomen-de HoopEsther van MeertenRon H N van SchaikRon H J MathijssenSander Bins

Published in: Clinical pharmacokinetics (2023)

Our study indicates that ABCG2 and CES1 SNPs might be used as predictive markers for irinotecan-induced toxicity.

Keyphrases

oxidative stress
high glucose
diabetic rats
drug induced
gene expression