Platelet-mediated circulating tumor cell evasion from natural killer cell killing through immune checkpoint CD155-TIGIT.
Yun-Fan SunTong LiLin DingJiyan WangChen ChenTe LiuYu LiuQian LiChuyu WangRan HuoHao WangTongtong TianChunyan ZhangBaishen PanJian ZhouJia FanXinrong YangWenjing YangBeili WangWei GuoPublished in: Hepatology (Baltimore, Md.) (2024)
Our results demonstrated CTC evasion from NK-cell-mediated innate immunosurveillance mainly through immune checkpoint CD155-TIGIT, potentially offering an immunotherapeutic strategy for eradicating CTCs.