Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.

Alessandro Ottaiano Nicola NormannoSergio FacchiniAntonino CassataAnna NappiCarmela RomanoLucrezia SilvestroAlfonso De StefanoAnna Maria RachiglioCristin RomaMonica R MaielloStefania Scala Paolo Delrio Fabiana Tatangelo Annabella Di MauroGerardo BottiAntonio AvalloneGuglielmo Nasti

Published in: Cancers (2020)

We show that mutant KRAS is a negative prognostic factor and that p.G12C/p.G12S variants present the worst clinical courses. This information suggests a clear difference among KRAS mutations, and it will be useful to test potentiated and/or innovative therapeutic strategies in p.G12C/p.G12S metastatic CRC patients.

Keyphrases

prognostic factors
wild type
metastatic colorectal cancer
end stage renal disease

small cell lung cancer
newly diagnosed
ejection fraction
chronic kidney disease

squamous cell carcinoma
peritoneal dialysis
healthcare
dna methylation

patient reported outcomes
gene expression
copy number