Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.
Alessandro OttaianoNicola NormannoSergio FacchiniAntonino CassataAnna NappiCarmela RomanoLucrezia SilvestroAlfonso De StefanoAnna Maria RachiglioCristin RomaMonica R MaielloStefania ScalaPaolo DelrioFabiana TatangeloAnnabella Di MauroGerardo BottiAntonio AvalloneGuglielmo NastiPublished in: Cancers (2020)
We show that mutant KRAS is a negative prognostic factor and that p.G12C/p.G12S variants present the worst clinical courses. This information suggests a clear difference among KRAS mutations, and it will be useful to test potentiated and/or innovative therapeutic strategies in p.G12C/p.G12S metastatic CRC patients.