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Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant.

Kate R SecombeImogen A BallJoseph ShirrenAnthony D WignallDorothy M KeefeJoanne M Bowen
Published in: Breast cancer (Tokyo, Japan) (2020)
A reproducible diarrhea model was developed in both female and male rats, which indicated that diarrhea pathogenesis is multifactorial, including anatomical disruption particularly evident in the distal ileum, and alterations in microbial composition.
Keyphrases
  • irritable bowel syndrome
  • clostridium difficile
  • microbial community
  • high glucose
  • diabetic rats
  • drug induced
  • risk assessment
  • positive breast cancer