Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant.

Kate R SecombeImogen A BallJoseph ShirrenAnthony D WignallDorothy M KeefeJoanne M Bowen

Published in: Breast cancer (Tokyo, Japan) (2020)

A reproducible diarrhea model was developed in both female and male rats, which indicated that diarrhea pathogenesis is multifactorial, including anatomical disruption particularly evident in the distal ileum, and alterations in microbial composition.

Keyphrases

irritable bowel syndrome
clostridium difficile
microbial community
high glucose
diabetic rats
drug induced
risk assessment
positive breast cancer