Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease.
Koji KamagataChristina AndicaKaito TakabayashiYuya SaitoToshiaki TaokaHayato NozakiJunko KikutaShohei FujitaAkifumi HagiwaraKouhei KamiyaAkihiko WadaToshiaki AkashiKatsuhiro SanoMitsuo NishizawaMasaaki HoriShinji NaganawaShigeki Aokinull nullPublished in: Neurology (2022)
Our study indicates that changes in PVS-related MRI parameters occur in MCI and AD, possibly due to impairment of the glymphatic system. We also report the associations between MRI parameters and Aβ deposition, neuronal change, and cognitive impairment in AD.