Phase Formation, Mechanical Strength, and Bioactive Properties of Lithium Disilicate Glass-Ceramics with Different Al 2 O 3 Contents.

Owing to its excellent mechanical properties and aesthetic tooth-like appearance, lithium disilicate glass-ceramic is more attractive as a crown for dental restorations. In this study, lithium disilicate glass-ceramics were prepared from SiO 2 -Li 2 O-K 2 O-P 2 O 5 -CeO 2 glass systems with various Al 2 O 3 contents. The mixed glass was then heat-treated at 600 °C and 800 °C for 2 h to form glass-ceramic samples. Phase formation, microstructure, mechanical properties and bioactivity were investigated. The phase formation analysis confirmed the presence of Li 2 Si 2 O 5 in all the samples. The glass-ceramic sample with an Al 2 O 3 content of 1 wt% showed rod-like Li 2 Si 2 O 5 crystals that could contribute to the delay in crack propagation and demonstrated the highest mechanical properties. Surface treatment with hydrofluoric acid followed by a silane-coupling agent provided the highest micro-shear bond strength for all ceramic conditions, with no significant difference between ceramic samples. The biocompatibility tests of the material showed that Al 2 O 3 -added lithium disilicate glass-ceramic sample was bioactive, thus activating protein production and stimulating the alkaline phosphatase (ALP) activity of osteoblast-like cells.