Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinoma.

Shang LiGert Jan MeersmaJolanta KupryjanczykSteven de JongG Bea A Wisman

Published in: Journal of translational medicine (2024)

Our study shows that ARID1A loss is related to the differential methylation of a number of genes in OCCC. ARID1A-dependent DM genes have been identified as key genes of many cancer-related pathways that may provide new candidates for OCCC targeted treatment.

Keyphrases

genome wide
dna methylation
copy number
gene expression
clear cell
bioinformatics analysis
genome wide identification
insulin resistance
replacement therapy