Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease.
Eiman SolimanSarah OhrndorfMagdy ZehairyKhaled MatrawyAbeer AlhadidyAbeer Ali AbdelatiPublished in: BMC musculoskeletal disorders (2024)
The raised OPG and lower OPN in FDRs than in controls reflect an altered bone metabolism which could precede clinical disease phase. OPN and OPG could serve as markers of altered preclinical bone metabolism in FDRs of RA. US7 score might be a useful screening tool to identify 'at-risk' individuals.
Keyphrases
- rheumatoid arthritis
- bone mineral density
- disease activity
- soft tissue
- bone loss
- ankylosing spondylitis
- stem cells
- bone regeneration
- interstitial lung disease
- computed tomography
- systemic lupus erythematosus
- risk assessment
- nuclear factor
- body composition
- human health
- systemic sclerosis
- inflammatory response
- bone marrow