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Effects of dental implant surface biomodification with Limosilactobacillus reuteri on early bone healing: an experimental animal study.

Mustafa OzcanWim TeughelsBahar AlkayaOnur Ucak TurerFariz SalimovH G KayhanH S YıldızCenk M Haytac
Published in: Beneficial microbes (2024)
The aim of this animal study was to compare the primary/secondary stability and micro-CT bone and tissue volumes of implants that were immersed in Limosilactobacillus reuteri, cholecalciferol-D3 (vitamin D) and injectable platelet-rich fibrin (i-PRF) suspensions/solutions before placement in bone. 40 implants (10 in each group) were placed in the iliac crest of 5 sheep. The implants were immersed in L. reuteri, vitamin D or i-PRF solutions for five minutes before placement or left unsoaked as controls. Implant stability was determined by ISQ values and bone volume around implants was histomorphometrically analysed by micro-CT evaluation. At 4 weeks, implants in the L. reuteri group showed the highest secondary stability and 2- and 3D BV/TV values. Both L. reuteri and vitamin D immersed implants had higher osseointegration values compared to the implants in the i-PRF group and controls. There were no statistical differences between L. reuteri and vitamin D immersed implants. Within the limits of the study, the results suggest that immersing implants in L. reuteri or vitamin D suspensions/solutions before implant placement in bone may have beneficial effects on osseointegration.
Keyphrases
  • soft tissue
  • bone mineral density
  • computed tomography
  • contrast enhanced
  • ultrasound guided
  • magnetic resonance imaging
  • postmenopausal women
  • bone regeneration
  • positron emission tomography
  • pet ct