Germline susceptibility from broad genomic profiling of pediatric brain cancers.
Elaine R MardisSamara L PotterKathleen M SchiefferElizabeth A VargaMariam T MathewHeather M CostelloGregory WheelerBenjamin J KellyKatherine E MillerElizabeth A R GarfinkleRichard K WilsonCatherine E CottrellPublished in: Neuro-oncology advances (2024)
We outline our aggregate findings on cancer predisposition within this cohort which identified 16% of individuals (27 of 168) harboring a variant predicting cancer susceptibility and contextualize the impact of these results in terms of treatment-related aspects of precision oncology.