Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells.

Neng WangQi WangHailin TangFengxue ZhangYifeng ZhengShengqi WangJin ZhangZhiyu WangXiaoming Xie

Published in: Journal of experimental & clinical cancer research : CR (2017)

Taken together, our results suggest that ACTN4 plays an important role in breast CSCs-related metastasis and is a novel therapeutic target of EA treatment.

Keyphrases

cancer stem cells
epithelial mesenchymal transition
cell proliferation
young adults
signaling pathway
replacement therapy