Therapeutic Drug Monitoring of Endoxifen for Tamoxifen Precision Dosing: Feasible in Patients with Hormone-Sensitive Breast Cancer.
C Louwrens BraalAgnes JagerEsther Oomen-de HoopJustin D WestenbergKoen M W T LommenPeter de BruijnMijntje B VastbinderQuirine C van Rossum-SchornagelMartine F Thijs-VisserRobbert J van AlphenLiesbeth E M StruikHanneke J M ZuetenhorstRon H J MathijssenStijn L W KoolenPublished in: Clinical pharmacokinetics (2021)
This study demonstrated that it is feasible to increase the percentage of patients with endoxifen levels ≥ 16 nM using TDM. TDM is a safe strategy that offers the possibility of nearly halving the number of patients with endoxifen levels < 16 nM.