Coronavirus Disease 2019 (COVID-19) in a Patient with Disseminated Histoplasmosis and HIV-A Case Report from Argentina and Literature Review.
Fernando A MessinaEmmanuel MarinDiego H CáceresMercedes RomeroRoxana DepardoMaria M PriaroneLaura ReyMariana VázquezPaul E VerweijTom M ChillerGabriela SantisoPublished in: Journal of fungi (Basel, Switzerland) (2020)
The disease caused by the new SARS-CoV-2, known as Coronavirus disease 2019 (COVID-19), was first identified in China in December 2019 and rapidly spread around the world. Coinfections with fungal pathogens in patients with COVID-19 add challenges to patient care. We conducted a literature review on fungal coinfections in patients with COVID-19. We describe a report of a patient with disseminated histoplasmosis who was likely infected with SARS-CoV-2 and experienced COVID-19 during hospital care in Buenos Aires, Argentina. This patient presented with advanced HIV disease, a well-known factor for disseminated histoplasmosis; on the other hand, we suspected that COVID-19 was acquired during hospitalization but there is not enough evidence to support this hypothesis. Clinical correlation and the use of specific Histoplasma and COVID-19 rapid diagnostics assays were key to the timely diagnosis of both infections, permitting appropriate treatment and patient care.
Keyphrases
- coronavirus disease
- sars cov
- respiratory syndrome coronavirus
- case report
- antiretroviral therapy
- healthcare
- hepatitis c virus
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv testing
- palliative care
- hiv aids
- emergency department
- high throughput
- men who have sex with men
- pulmonary embolism
- adverse drug
- combination therapy
- electronic health record
- replacement therapy