Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB1 receptor in the ventromedial hypothalamus.
Asmat Ullah KhanLuiz Luciano Falconi-SobrinhoTayllon Dos Anjos-GarciaMaria de Fátima Dos Santos SampaioJosé Alexandre de Souza CrippaLeda Menescal-de-OliveiraNorberto Cysne CoimbraPublished in: Psychopharmacology (2020)
These findings suggest that CBD causes panicolytic-like effects and reduces unconditioned fear-induced antinociception when administered in the VMH, and these effects are mediated by the CB1 receptor-endocannabinoid signalling mechanism in VMH.