The role of osteopontin in oral cancer: A brief review with emphasis on clinical applications.
Erison Santana Dos SantosJoab Cabral RamosAna Luiza Oliveira Corrêa RozaBruno Augusto Linhares Almeida MarizAdriana Franco Paes LemePublished in: Oral diseases (2020)
Osteopontin (OPN) is a calcium-binding glycol-phosphoprotein present in many physiologic and pathological processes. This protein can control bone cell adhesion, osteoclastic activity, and bone matrix mineralization. However, its participation in pathological processes such as atherosclerosis, sarcoidosis, tuberculosis, and cancer have been described. Some studies have shown that OPN may participate in the development and progression of oral cancer. Although the role of OPN in oral cancer is not fully understood, some studies have suggested that this protein may induce malignant phenotype of cells by activation of PI3K/AKT/mTOR pathway, which favors cell proliferation, invasion, metastasis, angiogenesis, and failure of treatment. This review discusses the possible mechanism of involvement of OPN in oral cancer and its potential clinical application in diagnosis and prognosis.
Keyphrases
- cell adhesion
- cell proliferation
- bone mineral density
- induced apoptosis
- protein protein
- case control
- papillary thyroid
- endothelial cells
- mycobacterium tuberculosis
- cardiovascular disease
- physical activity
- amino acid
- emergency department
- cell cycle
- cell cycle arrest
- bone loss
- small molecule
- type diabetes
- cell death
- bone regeneration
- postmenopausal women
- oxidative stress
- vascular endothelial growth factor
- hepatitis c virus
- transcription factor
- pi k akt
- pulmonary tuberculosis
- adverse drug
- wound healing
- replacement therapy