Minimal Residual Disease Detection Using Gene Scanning Analysis, Fluorescent Fragment Analysis, and Capillary Electrophoresis for IgH Rearrangement in Adult B-Lineage Acute Lymphoblastic Leukemia: A Cross-Sectional Study.
Sepideh ShahkaramiSamareh YounesianShahrbano RostamiFarzad KompaniDavood BashashSeyed Asadollah MousaviSeyed H GhaffariPublished in: Cell journal (2023)
It seems that the PCR-based GeneScan analysis of IGH gene rearrangement detection may be a valuable molecular technique to distinguish monoclonality from polyclonality. And also, it may be a precise tool to detect the residual leukemic DNA in the PB follow-up samples of patients.
Keyphrases
- acute lymphoblastic leukemia
- capillary electrophoresis
- end stage renal disease
- label free
- real time pcr
- copy number
- chronic kidney disease
- ejection fraction
- genome wide
- newly diagnosed
- mass spectrometry
- loop mediated isothermal amplification
- prognostic factors
- high resolution
- gene expression
- dna methylation
- living cells
- cell free
- genome wide identification
- patient reported outcomes
- data analysis
- sensitive detection