Multiplexing Homocysteine into First-Tier Newborn Screening Mass Spectrometry Assays Using Selective Thiol Derivatization.
C Austin PickensElya CourtneySamantha L IsenbergCarla CuthbertKonstantinos PetritisPublished in: Clinical chemistry (2023)
Here we present the first known validated method capable of screening tHcy in DBS during FIA-MS/S first-tier NBS.
Keyphrases
- mass spectrometry
- liquid chromatography
- high performance liquid chromatography
- ms ms
- gas chromatography
- multiple sclerosis
- tandem mass spectrometry
- high resolution
- deep brain stimulation
- high resolution mass spectrometry
- liquid chromatography tandem mass spectrometry
- simultaneous determination
- ultra high performance liquid chromatography
- solid phase extraction