Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.
Riham R E AbouleisaAbou Bakr M SalamaQinghui OuXian-Liang TangMitesh SolankiYiru GuoYibing NongLindsey McNallyPawel Konrad LorkiewiczKamal M KassemBrooke M AhernKrishna ChoudharyReuben ThomasYu HuangHamzah R JuhardeenAisha SiddiqueZainab IfthikarSally K HammadAyman S ElbazKathryn N IveyDaniel J ConklinJonathan SatinBradford G HillDeepak SrivastavaRoberto BolliTamer M A MohamedPublished in: Circulation (2022)
This study provides mechanistic insights into the process of forced cardiomyocyte proliferation and advances the clinical feasibility of this approach by minimizing the oncogenic potential of the cell cycle factors owing to the use of a novel transient and cardiomyocyte-specific viral construct.