Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD.

Nicholas D JohnsonXiumei WuChristopher D StillXin ChuAnthony T PetrickGlenn S GerhardKaren N ConneelyJohanna Kay DiStefano

Published in: Clinical epigenetics (2021)

These findings are consistent with DNAm as a mechanism underpinning or marking fibrosis-related shifts in cell composition and demonstrate the potential of DNAm as a possible biomarker of NAFLD fibrosis.

Keyphrases

dna methylation
nk cells
single cell
gene expression
genome wide
systemic sclerosis
liver fibrosis
idiopathic pulmonary fibrosis
risk assessment
climate change