Biomimetic surfaces with special wettability have received much attention due to their promising prospects in droplet manipulation. Although some progress has been made, the manipulation of droplets by macroscopic defects of the millimeter structure and the wetting-state transition mechanism have rarely been reported. Herein, inspired by lotus leaves and desert beetles, biomimetic surfaces with macroscopic defects are prepared by laser processing and chemical modification. Various functions of droplet manipulation are achieved by controlling the millimeter-scale macroscopic defects, such as droplet capture, motion trajectory changing, and liquid well. And a droplet bottom expansion phenomenon is proposed: wetting-state transition in superhydrophobic regions around defects. The "edge failure effect" is proposed to explain the force analysis of droplet capture and the droplet bottom expansion to distinguish it from the adhesion phenomenon presented by the droplet sliding. 53.28° is defined as the expanded saturated angle of the as-prepared surface, which is used to distinguish whether the defect could cause the droplet bottom expansion. An enhanced edge failure effect experiment is designed to make the droplet bottom expansion more intuitive. This work provides a mechanistic explanation of the surfaces that utilize macroscopic defects for droplet manipulation. It can be applied to the monitoring of droplet storage limits, providing a perspective on the design and optimization of superhydrophobic surfaces with droplet manipulation.