Cerebral venous sinus thrombosis after COVID-19 vaccination: a case report and literature review.
Mohamed ElfilMohammad AladawiDmitry BalianIsmail FahadDaniel J ZhouBrian Villafuerte-TrisoliniThomas Scott DiesingPublished in: Oxford medical case reports (2023)
As COVID-19 vaccines became widely available, there have been reports of neurovascular complications. In this article, we aim to report a case of cerebral venous sinus thrombosis (CVST) induced by COVID-19 vaccination, with a literature review on similar cases as well as the potential pathophysiological mechanisms. Our case is a healthy male who developed headache, vomiting, photophobia and diplopia after receiving the Ad26.COV2.S vaccine. Fundus examination showed papilledema, and magnetic resonance imaging of the brain and cerebral veins showed CVST involving the superior sagittal sinus and right transverse sinus extending into the right jugular vein. Hypercoagulability workup was unremarkable, and the patient received immunotherapy and anticoagulation. Following this treatment, symptoms resolved, and he had no residual neurologic deficits. Developing neurologic manifestations, especially severe headaches with papilledema, after COVID-19 vaccination should warrant neuroimaging. Early recognition and management of CVST are essential for good clinical outcomes.
Keyphrases
- sars cov
- coronavirus disease
- magnetic resonance imaging
- respiratory syndrome coronavirus
- subarachnoid hemorrhage
- pulmonary embolism
- cerebral ischemia
- traumatic brain injury
- atrial fibrillation
- computed tomography
- brain injury
- venous thromboembolism
- inferior vena cava
- white matter
- resting state
- combination therapy
- drug induced
- sleep quality
- adverse drug
- cerebral blood flow
- diffusion weighted imaging