Effects of transforming growth factor-β1 on plasminogen activation in stem cells from the apical papilla: role of activating receptor-like kinase 5/Smad2 and mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signalling.

M C ChangH H ChangW C HsiehW L HuangY C LianP Y JengY L WangS Y YeungJiiang-Huei Jeng

Published in: International endodontic journal (2020)

TGF-β1 may affect the repair/regeneration activities of SCAP via differential increase or decrease of PAI-1, uPA and uPAR. These effects induced by TGF-β1 are associated with ALK5/Smad2/3 and MEK/ERK activation. Elucidation the signalling pathways and effects of TGF-β1 is useful for treatment of immature teeth with open apex by revascularization/revitalization procedures and tissue repair/regeneration.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
signaling pathway
pi k akt
protein kinase
stem cells
cell proliferation
minimally invasive
percutaneous coronary intervention
coronary artery bypass grafting
coronary artery disease
wound healing
advanced non small cell lung cancer
binding protein