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The Immune Microenvironment in Hormone Receptor-Positive Breast Cancer Before and After Preoperative Chemotherapy.

Adrienne G WaksDaniel G StoverJennifer L GuerrieroDeborah DillonWilliam T BarryEvisa GjiniChristina HartlWesley LoJennifer SavoieJane BrockRobert WesolowskiZaibo LiAdrienne DamicisAnne V PhilipsYun WuFei YangAmy SullivanPatrick DanaherHeather Ann BrauerWafa OsmaniMikel LipschitzKatherine A HoadleyMichael S GoldbergCharles M PerouScott RodigEric P WinerIan E KropElizabeth A MittendorfSara M Tolaney
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
The immune microenvironment of HR+/HER2- tumors differs according to tumor biology. This cohort of paired pre-/postchemotherapy samples suggests a critical role for immunosuppressive macrophage expansion in residual disease. The role of macrophages in chemoresistance should be explored, and further evaluation of macrophage-targeting therapy is warranted.
Keyphrases
  • positive breast cancer
  • stem cells
  • adipose tissue
  • patients undergoing
  • locally advanced
  • drug delivery
  • mesenchymal stem cells
  • cancer stem cells