The Immune Microenvironment in Hormone Receptor-Positive Breast Cancer Before and After Preoperative Chemotherapy.
Adrienne G WaksDaniel G StoverJennifer L GuerrieroDeborah DillonWilliam T BarryEvisa GjiniChristina HartlWesley LoJennifer SavoieJane BrockRobert WesolowskiZaibo LiAdrienne DamicisAnne V PhilipsYun WuFei YangAmy SullivanPatrick DanaherHeather Ann BrauerWafa OsmaniMikel LipschitzKatherine A HoadleyMichael S GoldbergCharles M PerouScott RodigEric P WinerIan E KropElizabeth A MittendorfSara M TolaneyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
The immune microenvironment of HR+/HER2- tumors differs according to tumor biology. This cohort of paired pre-/postchemotherapy samples suggests a critical role for immunosuppressive macrophage expansion in residual disease. The role of macrophages in chemoresistance should be explored, and further evaluation of macrophage-targeting therapy is warranted.