Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis.
Serdal ArslanNil Özbilum ŞahinBurcu BayyurtÖcal BerkanMehmet Birhan YılmazMehmet AşamFurkan AyazPublished in: Molecular diagnosis & therapy (2023)
In our study, 345 DEGs were found to be statistically significant (p < 0.05; FC > 2) between CAP and IMA. Of these, 65 were lncRNA and 280 were mRNA. Thirty-three lncRNAs were upregulated, while 32 lncRNAs were downregulated. Some of the important mRNAs are SPP1, CYP4B1, CHRDL1, MYOC, and ALKAL2, while some of the lncRNAs are LOC105377123, LINC01857, DIO3OS, LOC101928134, and KCNA3 between CAP and IMA tissue. We also identified genes that correlated with statistically significant lncRNAs. The results of this study are expected to be an important source of data in the development of new genetically based drugs to prevent atherosclerotic plaque. In addition, the data obtained may contribute to the explanation of the epigenetic mechanisms that play a role in the pathological basis of the process that protects the IMA from atherosclerosis.
Keyphrases
- genome wide analysis
- coronary artery
- genome wide identification
- network analysis
- long non coding rna
- cardiovascular disease
- electronic health record
- cell proliferation
- type diabetes
- genome wide
- gene expression
- dna methylation
- transcription factor
- coronary artery disease
- long noncoding rna
- pulmonary arterial hypertension
- big data