Effects of the cortisol milieu on tumor-infiltrating immune cells (TIICs) in corticotroph tumors.

Maki Kanzawa Hiroki Shichi Keitaro KanieMasaaki YamamotoNaoki YamamotoYasutaka Tsujimoto Hironori BandoGenzo IguchiShigehisa Kitano Naoko Inoshita Shozo Yamada Wataru Ogawa Tomoo Itoh Hidenori Fukuoka

Published in: Endocrinology (2024)

We found the possibility that ACTHomas were immunologically cold in a cortisol-independent manner. In contrast, the tumor infiltration of CD4+ cells and M2-macrophages were associated with the cortisol milieu. Future studies are needed to validate these results and develop effective immunotherapy while considering the cortisol milieu.

Keyphrases

induced apoptosis
magnetic resonance
oxidative stress
cell proliferation
case control
contrast enhanced