Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood.

Tobias MöllersHannah StockerLaura PernaAndreas NabersDan RujescuAnnette M HartmannBernd HolleczekBen SchöttkerKlaus GerwertHermann Brenner

Published in: Alzheimer's research & therapy (2021)

Our results support that AD pathology may be detectable and associated with reduced weight even in middle adulthood, many years before clinical diagnosis of AD. Physical activity might reduce the risk of onset of AD symptoms.

Keyphrases

body mass index
physical activity
weight gain
depressive symptoms
sleep quality
weight loss