Pre-existing Autoantibodies Neutralizing High Concentrations of Type I Interferons in Almost 10% of COVID-19 Patients Admitted to Intensive Care in Barcelona.
Xavier SolanichRaúl Rigo-BonninVictor-David GumucioPaul BastardJérémie RosainQuentin PhilippotXosé-Luis Perez-FernandezMaria-Paz Fuset-CabanesMiguel-Ángel Gordillo-BenitezGuillermo Suarez-CuartinEnric Boza-HernandezAntoni Riera-MestreAlba Parra-MartínezRoger ColobranArnau AntolíSergio NavarroGemma Rocamora-BlanchMario FramilLaura CalatayudXavier CorbellaJean-Laurent CasanovaFrancisco MorandeiraJoan Sabater-RieraPublished in: Journal of clinical immunology (2021)
Auto-Abs neutralizing high concentrations of type I IFNs were found in 9.5% of patients admitted to the ICU for COVID-19 pneumonia in a hospital in Barcelona. These auto-Abs should be tested early upon diagnosis of SARS-CoV-2 infection, as they account for a significant proportion of life-threatening cases.