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Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality.

Madeleine CarbonneauYi LiBrenton R PrescottChunyu LiuTianxiao HuanRoby JoehanesJoanne M MurabitoNancy Heard- CostaVanessa XanthakisDaniel LevyJiantao Ma
Published in: Journal of the American Heart Association (2024)
DNA methylation-based epigenetic age scores mediate the associations between the LE8 score and incident CVD, CVD-specific mortality, and all-cause mortality, particularly in individuals with higher genetic predisposition for older epigenetic age.
Keyphrases
  • dna methylation
  • cardiovascular disease
  • genome wide
  • gene expression
  • cardiovascular events
  • physical activity
  • copy number
  • type diabetes
  • metabolic syndrome
  • community dwelling
  • middle aged