RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.

Gunjan SharmaTiffany M TranIshu BansalMohammad Sabique BegRuchi BhardwajJaspal BassiYuande TanAmit Kumar JaiswalChristine TsoAyushi JainJay SinghParthaprasad ChattopadhyayArchna SinghAnita ChopraSameer BakhshiDavid CaseroDinesh S RaoJayanth Kumar P

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our data suggest a combined impact of the ETV6::RUNX1 fusion protein and RNA binding protein, IGF2BP1 in activating multiple oncogenic pathways in B-ALL which makes IGF2BP1 and these pathways as attractive therapeutic targets and biomarkers.

Keyphrases

binding protein
acute lymphoblastic leukemia
transcription factor
allogeneic hematopoietic stem cell transplantation
signaling pathway
nucleic acid
pi k akt
cell proliferation
machine learning