Regulation of Microtubule Stability in Pulmonary Microvascular Endothelial Cells in Rats with Severe Acute Pancreatitis: Qingyi Decoction is a Potential CDK5 Inhibitor.

Yinan CaoFan LiZhen-Xuan SunJin LiuJie LiuQi YangPeng GeYalan LuoHailong Chen

Published in: Journal of inflammation research (2024)

CDK5 has been identified as a critical target for pulmonary endothelial injury of SAP-ALI. QYD may partially alleviate microtubule disassembly by targeting the CDK5/NFAT5/GEF-H1 signaling pathway, thus relieving SAP-induced pulmonary microvascular endothelial cell injury.

Keyphrases

endothelial cells
high glucose
pulmonary hypertension
cell cycle
signaling pathway
vascular endothelial growth factor
drug induced
epithelial mesenchymal transition
pi k akt
early onset
cell proliferation
oxidative stress
risk assessment