Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non-Small Cell Lung Cancer - The Piedmont Study.

Joel R Eisner Gregory M Mayhew James M Davison Kirk D Beebe Yoichiro Shibata Yuelong Guo Carol J Farhangfar Farhang Farhangfar Joshua M Uronis Jeffrey M Conroy Michael V Milburn David Neil Hayes Kathryn F Mileham

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

AF-PRS identified a significant population of patients with extended PFS and/or clinical response following PMX-PDC treatment. AF-PRS may be a useful diagnostic test for patients indicated for systemic chemotherapy, especially when determining the optimal PDC regimen for locally advanced disease.

Keyphrases

atrial fibrillation
ejection fraction
small cell lung cancer
end stage renal disease
newly diagnosed
prognostic factors
squamous cell carcinoma
radiation therapy
advanced non small cell lung cancer
tyrosine kinase