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Somatic TET2 Mutations are Associated with Giant Cell Arteritis.

Michelle L RobinetteLachelle D WeeksRyan J KramerMridul AgrawalChristopher J GibsonZhi YuAswin SekarArnav MehtaAbhishek NiroulaJared T BrownGregory C McDermottEdith R ReshefJonathan E LuVictor D LiouCarolina A ChiouPradeep NatarajanSuzanne K FreitagDeepak A RaoBenjamin L Ebert
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
CH increases risk for development of GCA in a genotype-specific fashion, with greatest risk being conferred by the presence of mutations in TET2. Somatic TET2 mutations likewise increase the risk of GCA-associated vision loss. Integration of somatic genetic testing in GCA diagnostics may be warranted in the future. This article is protected by copyright. All rights reserved.
Keyphrases
  • giant cell
  • copy number
  • gene expression
  • dna methylation
  • current status
  • room temperature
  • ionic liquid