Somatic TET2 Mutations are Associated with Giant Cell Arteritis.

Michelle L RobinetteLachelle D WeeksRyan J KramerMridul AgrawalChristopher J GibsonZhi YuAswin SekarArnav MehtaAbhishek NiroulaJared T BrownGregory C McDermottEdith R ReshefJonathan E LuVictor D LiouCarolina A ChiouPradeep NatarajanSuzanne K FreitagDeepak A Rao Benjamin L Ebert

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

CH increases risk for development of GCA in a genotype-specific fashion, with greatest risk being conferred by the presence of mutations in TET2. Somatic TET2 mutations likewise increase the risk of GCA-associated vision loss. Integration of somatic genetic testing in GCA diagnostics may be warranted in the future. This article is protected by copyright. All rights reserved.

Keyphrases

giant cell
copy number
gene expression
dna methylation
current status
room temperature
ionic liquid