Somatic TET2 Mutations are Associated with Giant Cell Arteritis.
Michelle L RobinetteLachelle D WeeksRyan J KramerMridul AgrawalChristopher J GibsonZhi YuAswin SekarArnav MehtaAbhishek NiroulaJared T BrownGregory C McDermottEdith R ReshefJonathan E LuVictor D LiouCarolina A ChiouPradeep NatarajanSuzanne K FreitagDeepak A RaoBenjamin L EbertPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
CH increases risk for development of GCA in a genotype-specific fashion, with greatest risk being conferred by the presence of mutations in TET2. Somatic TET2 mutations likewise increase the risk of GCA-associated vision loss. Integration of somatic genetic testing in GCA diagnostics may be warranted in the future. This article is protected by copyright. All rights reserved.