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Multi-ancestral GWAS identifies shared and Asian-specific loci for SLE and links type III interferon signaling and lysosomal function to the disease.

Yong-Fei WangWei WeiPattarin TangtanatakulLichuan ZhengYao LeiZhiming LinChengmin QianXiao QinFei HouXinyu ZhangLi ShaoNusara SatproedpraiSurakameth MahasirimongkolPrapaporn PisitkunQin SongYu Lung LauYan ZhangNattiya HirankarnWanling Yang
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Multi-ancestral GWAS identified both shared and Asian-specific loci for SLE, and functional annotation pointed to the involvement of increased type III interferon signaling and reduced lysosomal function in SLE.
Keyphrases
  • type iii
  • systemic lupus erythematosus
  • genome wide
  • disease activity
  • genome wide association study
  • dendritic cells
  • rheumatoid arthritis
  • dna methylation
  • genome wide association