Abietane-Type Diterpenoids from the Arils of Torreya grandis .
Yuqi GaoJinghui YangYue ZhangLinlin GaoJun-Mian TianWenbo HanJinming GaoPublished in: Molecules (Basel, Switzerland) (2024)
A chemical investigation of the arils of Torreya grandis led to the isolation of seven abietane-type diterpenoids (compounds 1 - 7 ) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of these compounds were determined by means of spectroscopy, single-crystal X-ray diffraction, and ECD spectra. An antibacterial activity assay showed that compounds 5 and 6 had significant inhibitory effects on methicillin-resistant Staphylococcus aureus , with MIC values of 100 μM. Moreover, compounds 1 , 3 , 4 , and 7 exhibited anti-neuroinflammatory activity in LPS-stimulated BV-2 microglia cells, with the IC 50 values ranging from 38.4 to 67.9 μM.
Keyphrases
- methicillin resistant staphylococcus aureus
- high resolution
- inflammatory response
- staphylococcus aureus
- induced apoptosis
- high throughput
- magnetic resonance imaging
- computed tomography
- lps induced
- lipopolysaccharide induced
- molecular docking
- oxidative stress
- magnetic resonance
- signaling pathway
- spinal cord
- molecular dynamics
- density functional theory
- cell proliferation
- cell death
- anti inflammatory
- pi k akt
- single cell
- contrast enhanced