Single-cell RNA sequencing reveals localized tumour ablation and intratumoural immunostimulant delivery potentiate T cell mediated tumour killing.

Ashley R HooverKaili LiuChrista I DeVetteJason R KrawicAlexandra D MedcalfConnor L WestTomas HodeSamuel S K LamAlana L WelmXiao-Hong SunWilliam H HildebrandWei R Chen

Published in: Clinical and translational medicine (2022)

Overall, our results reveal that LAIT prompts immunological remodelling of T cells by inducing broad proinflammatory responses and inhibiting suppressive signalling to drive antitumour immunity.

Keyphrases

single cell
rna seq
high throughput
signaling pathway
radiofrequency ablation
catheter ablation
atrial fibrillation