Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study.
Zhanwei WangAnuradha S BudhuYi ShenLinda Lou WongBrenda Y HernandezMaarit TiirikainenXiaomei MaMelinda L IrwinLingeng LuHongyu ZhaoJoseph K LimTamar TaddeiLopa MishraKaren PawlishAntoinette StroupRobert BrownMindie H NguyenJill KoshiolMaria O HernandezMarshonna ForguesHwai-I YangMei-Hsuan LeeYu-Han HuangMotoki IwasakiAtsushi GotoShiori SuzukiKoichi MatsudaChizu TanikawaYoichiro KamataniDean MannMaria GuarneraKirti ShettyClaire E ThomasJian-Min YuanChiea Chuen KhorWoon-Puay KohHarvey RischXin Wei WangHerbert YuPublished in: JGH open : an open access journal of gastroenterology and hepatology (2021)
are known risk loci for nonalcoholic fatty liver disease (NAFLD) and are suspected to be associated with HCC. Our GWAS demonstrated the associations of these SNPs with HCC in a US population. Biological mechanisms underlying the relationship remain to be elucidated.