HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model.
Alice K MinBehnam JavidfarRoy MissallDonald DoanmanMadel DurensSamantha St VilZahra MasihMara GrazianiAnnika MordeltSamuele MarroLotje de WitteBenjamin K ChenTalia H SwartzSchahram AkbarianPublished in: bioRxiv : the preprint server for biology (2023)
, which is more challenging to study with current hematopoietic stem cell-based models for neuroHIV. Our transgenic tracing of xenografted human cells will provide a quantitative medium to develop new molecular and epigenetic strategies for reducing the HIV-1 latent reservoir and to test the impact of therapeutic inflammation-targeting drug interventions on CNS HIV-1 latency.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- hematopoietic stem cell
- human immunodeficiency virus
- hiv testing
- mouse model
- hiv aids
- hepatitis c virus
- men who have sex with men
- oxidative stress
- dna methylation
- gene expression
- inflammatory response
- blood brain barrier
- physical activity
- emergency department
- neuropathic pain
- cerebrospinal fluid
- spinal cord
- drug induced
- spinal cord injury
- mass spectrometry
- monoclonal antibody
- water quality