Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells.

Li-Oon ChuahHooi Ling FooTeck Chwen LohNoorjahan Banu Mohammed AlitheenSwee Keong YeapNur Elina Abdul MutalibRaha Abdul RahimKhatijah Yusoff

Published in: BMC complementary and alternative medicine (2019)

In conclusion, PM produced by the six strains of L. plantarum exhibited selective cytotoxic via antiproliferative effect and induction of apoptosis against malignant cancer cells in a strain-specific and cancer cell type-specific manner whilst sparing the normal cells. This reveals the vast potentials of PM from L. plantarum as functional supplement and as an adjunctive treatment for cancer.

Keyphrases

papillary thyroid
cell cycle arrest
escherichia coli
particulate matter
air pollution
induced apoptosis
squamous cell
oxidative stress
endoplasmic reticulum stress
heavy metals
cell death
squamous cell carcinoma
ms ms
cell proliferation
pi k akt
water soluble
combination therapy